Safety, Tolerability & Regulatory Status Safety Profile GHK-Cu demonstrates an excellent safety profile for cosmetic use: Naturally occurring in humans (plasma, saliva, urine) Non-sensitizing in standard patch testing at cosmetic concentrations Long history of topical application in anti-aging and wound care products Minimal reported adverse reactions at appropriate doses Usage Levels and Tolerability Regulatory Status EU : Permitted as a cosmetic ingredient with standard safety assessments US/Asia-Pacific : Allowed under respective cosmetic regulations Formulators must : Perform product-specific safety evaluations, including SDS review, toxicological profiles, and margin of safety calculations Addressing Copper Uglies Literature occasionally references theoretical over-stimulation of MMPs leading to collagen breakdown (sometimes called copper uglies)
If, and only if, a particular Adamax product is confirmed to be the same molecule as Semax (same sequence, same molecular weight of roughly 813.9 g/mol for Met-Glu-His-Phe-Pro-Gly-Pro), then the Semax concentration anchors apply directly: a 10mg vial in 1 mL is a 1% solution, in 10 mL is a 0.1% solution, and the mcg-per-unit table above holds without modification
Feel free to click through yourself, but here are some entertaining highlights: BPC-157 shortens bleeding time in rats and also boosts platelet aggregation and clot formation
K.SpormannA.et al (2015)
PMID 3550726
